MSU鈥檚 College of Veterinary Medicine receives $3.3 million NIH grant for chemical antidote research
Contact: Doug Bedsaul
STARKVILLE, Miss.鈥擜 Mississippi State William L. Giles Distinguished Professor with a long history of chemical antidote research is leading a newly funded $3.3 million project aimed at identifying better therapeutic medical countermeasures to protect the brain against chemical threats.
Janice Chambers, director of MSU鈥檚 Center for Environmental Health Sciences in the College of Veterinary Medicine, is receiving the new U01 grant, which is the university鈥檚 third award through the National Institutes of Health CounterACT program.
The five-year Optimization U01 grant is titled 鈥淥ptimization of Substituted Phenoxyalkyl Pyridinium Oximes as Therapies for Organophosphate Poisoning.鈥
Co-investigators include CVM faculty and staff Matthew Ross, Robert Wills, Edward Meek and Alicia Olivier.
Chambers said a major concern for survivors of a chemical attack is the potential for permanent brain damage caused by seizures. The brain cannot repair such damage easily, and Chambers said there is critical need for an antidote that can enter the brain to reverse early damage and prevent long-term effects.
Chambers鈥 team has been developing antidotes that will improve outcomes after exposure to threatening chemicals studying surrogates for nerve agents.
鈥淲e鈥檙e trying to develop an antidote that might replace or be used in conjunction with the currently approved antidote, so we can reverse some of the toxic effects in the brain to prevent or at least attenuate the brain damage. The current FDA-approved antidote cannot protect the victim鈥檚 brain,鈥 she explained.
The current antidote, which protects the heart, lungs and muscles, cannot cross the blood-brain barrier, a layer of cells between the blood and brain. Chambers said this barrier prevents many chemicals, including some drugs like the currently approved antidote, from moving from the blood into the brain.
鈥淚f approved, these antidotes would give more confidence to the public that not only could their lives be saved in such an event, but also their brain function could be preserved,鈥 she said. 鈥淥ur perspective is to try to save the life and the brain too, giving the person who is exposed to this type of poison the hope of a normal life after that event.鈥
Once approved, the antidote would be added to the Strategic National Stockpile of protective drugs and devices that is maintained by the Department of Health and Human Services to assist the public in the event of emergencies, such as terrorist attacks or accidents with these threat chemicals.
Chambers said she and her team will continue investigating the effectiveness of the novel antidote and will work to determine the best method for administering the potential drug for optimal protection and safety.
This research is supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number U01NS123255. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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